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 CD147/EMMPRIN/Basigin  抗體

All CD147 Reagents

反應性: Human  
應用 : ELISA  WB  
10186-RP01-400
10186-RP01-200
10186-RP01-100
400 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : ELISA  IHC-P  
10186-MM05-50
10186-MM05-200
10186-MM05-100
10186-MM05-1
50 µg 
200 µg 
100 µg 
1 mg 
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反應性: Human  
應用 : FCM  
10186-R125-A-25
10186-R125-A-100
25 Test 
100 Tests 
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反應性: Human  
應用 : ELISA  WB  IHC-P  FCM  IF  IP  IHC-Fr  ICC/IF  
10186-R125-50
10186-R125-100
50 µg 
100 µg 
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反應性: Human  
應用 : 
10186-R118-50
10186-R118-100
10186-R118-1
50 µg 
100 µg 
1 mg 
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    反應性: Human  
    應用 : FCM  
    10186-R125-P-25
    10186-R125-P-100
    25 Test 
    100 Tests 
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    反應性: Human  
    應用 : FCM  IF  ICC/IF  
    10186-MM08-F-25
    10186-MM08-F-100
    25 Test 
    100 Tests 
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    反應性: Human  
    應用 : FCM  
    10186-MM08-A-25
    10186-MM08-A-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    反應性: Human  
    應用 : ELISA  FCM  IF  ICC/IF  
    10186-MM08-50
    10186-MM08-200
    10186-MM08-100
    50 µg 
    200 µg 
    100 µg 
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    • Slide 1
    • Slide 1
    反應性: Human  
    應用 : FCM  
    10186-MM08-P-25
    10186-MM08-P-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    • Slide 1
    反應性: Human  
    應用 : ELISA  IHC-P  
    10186-RP02-50
    10186-RP02-200
    10186-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    • Slide 1
    反應性: Human  
    應用 : FCM  IF  ICC/IF  
    10186-R125-F-25
    10186-R125-F-100
    25 Test 
    100 Tests 
    Add to Cart
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    • Slide 1
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    Browse CD147/EMMPRIN/Basigin Products by

    CD147/EMMPRIN/Basigin 相关研究领域

    CD147/EMMPRIN/Basigin 相關信號通路

      CD147/EMMPRIN/Basigin 概述&蛋白信息

      CD147/EMMPRIN/Basigin 研究背景

      基因概述: The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
      General information above from NCBI
      亞單位結構: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. {ECO:0000250|UniProtKB:P18572, ECO:0000250|UniProtKB:P26453, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:17267690, ECO:0000269|PubMed:18430721, ECO:0000269|PubMed:19768682, ECO:0000269|PubMed:21536654}.
      亞細胞定位: Cell membrane {ECO:0000269|PubMed:15946952}; Single-pass type I membrane protein {ECO:0000303|PubMed:15946952}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:17081065}.
      組織特異性: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
      誘導: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
      翻譯後修飾: N-glycosylated. {ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973}.
      相似的序列: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
      General information above from UniProt

      CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

      CD147/EMMPRIN/Basigin 別稱

      CD147/EMMPRIN/Basigin 相關文獻

    • Tang Y, et al. (2004) Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2(2): 73-80.
    • Wilson MC, et al. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 280(29): 27213-21.
    • Curtin KD, et al. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci. 118(Pt 12): 2649-60.
    • Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44. Zhu H, et al. (2009) A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity. Cancer Biol Ther. 8(11): 1035-44.
    • Seizer P, et al. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 101(4): 682-6.
    • Moonsom S, et al. (2010) A Competitive ELISA for Quantifying Serum CD147: Reduction of Soluble CD147 Levels in Cancer Patient Sera. Hybridoma (Larchmt). 29(1): 45-52.
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