Host Defense Receptors as Drug Target

Host Defense Receptors as Drug Target Background

Host defense receptors, are referred to these receptors that play a key role in adaptive cellular and humoral immune responses, including complement receptors, Fc receptors and toll-like receptors. These receptors are perfect drug targets for a great many diseases.

CCR1 plays an important role in host defense and is involved in regulating the chemotaxis of immune cells, a feature it shares in common with all chemokine receptors. Dysregulation of this response leads to autoimmunity and CCR1 has been associated with the pathophysiology of a number of diseases including rheumatoid arthritis, multiple sclerosis, transplant rejection and allergic inflammatin.

Host Defense Receptors as Drug Target List

Category Drug target
Complement receptors
CR1 CR1L CR2 CFHR1
CFHR2 CFHR5    
Fc receptors
FCGR2A FCGR2B FCGR3A FCGR3B
FCGRT FCAMR FCAR FCER1A
MS4A2 FCER1G FCER2 FCRL1
FCRL2 FCRL3 FCRL4 FCRL5
FCRL6 FCRLA    
Toll-like receptors
TLR1 TLR2 TLR3 TLR4
TLR5 TLR6 TLR7 TLR8
TLR9 TLR10    
Killer cell immunoglobulin-like receptor
KIR2DL1 KIR2DL3 KIR2DL4 KIR2DL5A
KIR2DL5B KIR3DL1 KIR3DS1  
Killer cell lectin-like receptor
KLRC1 KLRC2 KLRC3 KLRD1
KLRF1 KLRG1 KLRK1  
Leukocyte immunoglobulin-like receptor
LILRA1 LILRA2 LILRA3 LILRA4
LILRA5 LILRB1 LILRB2 LILRB3
LILRB4 LILRB5 LAIR1 LAIR2
Natural cytotoxicity triggering receptor
NCR1 NCR2 NCR3 NCR3LG1
Triggering receptor expressed on myeloid cells
TREM1 TREM2 TREML1 TREML2
TREML4      
Other host defense receptors
BST1 BST2 CD3E CD3D
CD3G CD36 CD200R1 CD200R1L
PROCR CD244 ICOS MARCO
MILR1 PLGRKT PIGR TIGIT

References

1. Mannhold R, et al. Chemokine receptors as drug targets[M]. John Wiley & Sons, 2010.

2. Suresh R, et al. Pattern recognition receptors in innate immunity, host defense, and immunopathology[J]. Advances in physiology education, 2013, 37(4): 284-291.

Receptors
Receptors Classification
Receptors by Differentiation Cells
Receptors by Drug Target
GPCRs as Drug Target
GPCR Ligands as Drug Target
Nuclear Hormone Receptors as Drug Target
Cell Adhesion Receptors as Drug Target
Host Defense Receptors as Drug Target
Enzyme-Linked Receptors as Drug Target+
- Receptor Tyrosine Kinases as Drug Target
- Receptor Serine/Threonine Kinases as Drug Target
- Receptor Tyrosine Phosphatases as Drug Target
Other Receptors as Drug Target
Receptors by Functions
Receptors Reagent Products
Receptors by Species