Anti-c-MET Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Canine
Canine c-MET Has cross-reactivity in ELISA with Mouse MET No cross-reactivity in ELISA with Human HGFR
Recombinant Canine HGFR / c-MET protein (Catalog#70008-D08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Canine HGFR / c-MET (Catalog#70008-D08H; NP_001002963.1; Met1-Leu935).
Monoclonal Rabbit IgG Clone #202
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Please Note: Optimal concentrations/dilutions should be determined by the end user.
c-MET Background Information
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
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