快速訂購

Growth Factor Receptors

Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Growth factor receptors include wnt receptor, tie, neurotrophin receptor, ephrin receptor, insulin-like growth factor receptor (IGF receptor), epidermal growth factor receptor (EGF receptor), fibroblast growth factor receptor (FGF receptor), platelet-derived growth factor receptor (PDGF receptor) and vascular endothelial growth factor receptor (VEGF receptor), etc.

Growth factor receptors are transmembrane proteins which bind to specific growth factors and transmit the instructions conveyed by the factors to intracellular space. The growth factor receptors on cell surface are very common, and cells mainly contains receptors for several growth factors. Most growth factor receptors have a cysteine-rich region, which participate in signal transduction by receptor tyrosine kinase, e.g., the receptors for fibroblast growth factor ( FGF), vascular endothelial growth factor(VEGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF), etc. Meanwhile, there are some receptors which mediate the signal transduction via receptor serine-threonine kinase, such as the receptor for transforming growth factor β.

Growth Factor Receptor Molecules List

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Frizzled-1/FZD1 Frizzled-10/FZD10 (CD350) Frizzled-2/FZD2
Frizzled-4/FZD4/CD344 Frizzled-5/FZD5 Frizzled-6/FZD6
Frizzled-9/FZD9 LRP1 (CD91) LRP5
LRP6 VEGFR2/KDR/Flk-1/CD309 LRP8/ApoER2
FGFR2/CD332 VEGFR3/FLT-4 CD16-2/FCGR4
LRP10 LRP11 LRPAP1/A2MRAP
MUSK Tie1 Tie2/CD202b/TEK
NGFR/P75 NGFRAP1 TrkA/NTRK1
TrkB/NTRK2 TrkC/NTRK3 EphA1/Eph Receptor A1
EphA2/Eph Receptor A2 EPHA3/Eph Receptor A3 EphA4/Eph Receptor A4
EphA6 / EHK2 / Eph Receptor A6 EphA7/Eph Receptor A7 EphB1/Eph Receptor B1
EphB2/Eph Receptor B2 EphB3/HEK2/Eph Receptor B3 EphB4/Eph Receptor B4
EphB6/Eph Receptor B6 IGF1R/CD221/IGF-I R IGFLR1 / TMEM149
Insulin Receptor/INSR/CD220 EGFR/HER1 HER2/ERBB2
ERBB3/HER3 ERBB4/HER4 FGFR1/CD331
FGFR2/CD332 FGFR3/CD333 FGFR4/CD334
FGFRL1/FGFR5 FOP/FGFR1OP PDGFRA/CD140a
PDGFRB/CD140b PDGFRL Neuropilin-1/NRP1/CD304
NRP2/Neuropilin-2 VEGFR1/FLT-1 FLT3/CD135/FLK-2
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