FCRL1: FCRL1 Protein | FCRL1 Antibody

FCRL1 Gene family

FCRL1 Background

Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I  membrane protein which contains three Ig-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.

Reference for FCRL1

  • Du X. et al., 2008, Blood. 111 (1): 338-43.
  • Kazemi T. et al., 2008, Int J Cancer. 123 (9): 2113-9.
  • Baranov K. et al., 2008, J Immunol Methods. 332 (1-2): 73-81.

FCRL1 Protein

FCRL1 protein function

May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269|PubMed:15479727}.

FCRL1 protein expression

Tissue specificity

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).

Induction

Down-regulated in activated B-cells.

FCRL1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    429.00
  • Mass (Da)
    46.00

FCRL1 Antibody

There are 4 FCRL1 antibodies which are validated in multiple tissues with various applications, including ELISA, WB, IP. There are 4 FCRL1 antibody for ELISA, 1 FCRL1 antibody for WB, 1 FCRL1 antibody for IP. Among all these FCRL1 antibodies, there are 4 anti-FCRL1 rabbit polyclonal antibodies . All the FCRL1 anbodies are produced in house and all are in stock. FCRL1 antibody customerized service is available.

FCRL1 Gene

FCRL1 gene / cDNA is a protein-coding gene which located on 1q23.1. The FCRL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, and mouse.72 organisms have orthologs with human gene FCRL1.