Factor H cDNA Clone: Expression and Clone Vector / Plasmid

Factor H cDNA / Gene Overview

CFH gene / cDNA is a protein-coding gene which located on 1q31.3. The CFH gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.142 organisms have orthologs with human gene CFH.

Factor H cDNA / Gene Function

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]

Factor H cDNA / Gene Sequence

LOCUS
LOCUS NM_000186 4200 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
ACCESSION
NM_000186
VERSION
NM_000186.3

This sequence information is just for reference only.

Factor H Family & Reagents

Factor H Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C5
C7
CD59
CFD
CFHR2
Approved Symbol Reagent list
C2
C6
CD46
CFB
CFHR1
CR2

Factor H Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
APOH
C6
CD46
CFB
CFHR2
F13B
IL2RA
SELE
SELP
SUSD4
Approved Symbol Reagent list
C2
C7
CD55
CFHR1
CR2
HP
PAPPA2
SELL
SEZ6L2
TPO

Factor H cDNA / Gene Alias

  • age-related maculopathy susceptibility 1
  • ARMD4
  • ARMS1
  • beta-1H
  • FHL1
  • H factor 2 (complement)
  • HUS

Factor H cDNA / Gene Expression

Biased expression in liver (RPKM 390.3), gall bladder (RPKM 78.0) and 9 other tissues