Factor H cDNA Clone: Expression and Clone Vector / Plasmid
Factor H cDNA / Gene Overview
CFH gene / cDNA is a protein-coding gene which located on 1q31.3. The CFH gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.142 organisms have orthologs with human gene CFH.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Factor H cDNA / Gene Sequence
LOCUS NM_000186 4200 bp mRNA linear PRI 22-JUL-2018
Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
This sequence information is just for reference only.
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