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EPHA8/Eph receptor A8  Protein, Antibody, ELISA Kit, cDNA Clone

EPHA8/Eph receptor A8 相关研究领域

EPHA8/Eph receptor A8 相關信號通路

EPHA8/Eph receptor A8 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EPHA8/Eph receptor A8 概述&蛋白信息

EPHA8/Eph receptor A8 研究背景

催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers with other ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination. {ECO:0000250, ECO:0000269|PubMed:10498895, ECO:0000269|PubMed:11416136, ECO:0000269|PubMed:17875921, ECO:0000269|PubMed:20496116}.
亞細胞定位: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}.
翻譯後修飾: Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity). {ECO:0000250}.; Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity). {ECO:0000250}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

EPHA8/Eph receptor A8 別稱

EEK,EK3,HEK3, [homo-sapiens]
Eek,Hek3,AW047546,mKIAA1459, [mus-musculus]

EPHA8/Eph receptor A8 相關文獻

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