Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse

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Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse General Information

Product name
Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Mouse Endoglin / CD105
Assay range
31.25-2000 pg/mL
Materials provided
1. Capture Antibody 1.0 mg/mL of rabbit anti-mouse ENG monoclonal antibody. Dilute to a working concentration of 0.5 μg/mL in CBS before coating. (Catalog: # 50407-R029)
2. Detection Antibody 0.5 mg/mL rabbit anti-mouse ENG monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 50407-R028)
3. Standard Each vial contains 88 ng of recombinant mouse ENG. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 2 ng/mL is recommended.
Product overview
This Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse is a solid phase sandwich ELISA for quantitative determination of Mouse Endoglin / CD105 . It contains Mouse Endoglin / CD105 capture antibody, Mouse Endoglin / CD105 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Mouse Endoglin / CD105 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse Images

Endoglin / CD105 Matched ELISA Antibody Pair Set,Mouse: Alternative Names

AI528660 Matched ELISA Antibody Pair Set, Mouse; AI662476 Matched ELISA Antibody Pair Set, Mouse; CD105 Matched ELISA Antibody Pair Set, Mouse; Endo Matched ELISA Antibody Pair Set, Mouse; S-endoglin Matched ELISA Antibody Pair Set, Mouse

Endoglin / CD105 Background Information

Endoglin, also known as CD15, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
Full Name
endoglin
References
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
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