Anti-Endoglin / CD105 Antibody

Endoglin, also known as CD15, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

endoglin

• Cancer>>Cancer Biomarker
• Stem Cells>>Cancer Stem Cells (CSCs)>>Cancer Stem Cell (CSC) Marker
• Immunology>>Cluster of Differentiation (CD)>>CD Antigen (Hematopoietic Stem Cell Markers)
• Stem Cells>>Endothelial Progenitors>>Endothelial Markers
• Stem Cells>>Hematopoietic Stem Cells (HSCs)>>Hematopoietic Stem Cell (HSC) Marker
• Immunology>>Cluster of Differentiation (CD)>>Monocyte/Macrophage CD Antigen>>Macrophage Marker CD Antigen
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Macrophage Markers
• Developmental Biology>>Embryogenesis>>Germ Layer Formation>>Mesoderm Marker
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Monocyte Markers
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Transforming Growth Factor Beta (TGF-beta) Superfamily>>Transforming Growth Factor Beta (TGF-beta) Family>>TGF-beta Family Receptor
• Stem Cells>>Stem Cell Signaling Pathways>>TGF-beta Signaling Pathway
• Cardiovascular>>Angiogenesis>>Cytokine & Receptor>>Transforming Growth Factor Beta (TGF-beta) Superfamily>>TGF-beta Superfamily Receptors

• Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
• Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
• Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.