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REG1B 抗體, 兔多抗

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
11638-H08H-20
11638-H08H-100
20 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90163-C02H-20
90163-C02H-100
20 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
90163-C08H-20
90163-C08H-100
20 µg 
100 µg 
Add to Cart

REG1B ELISA配對抗體

檢測限: 3.13 pg/ml
SEK11638-5
SEK11638-15
5 Plates 
15 Plates 
Add to Cart

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REG1B antibody 研究背景

Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

 REG1B antibody 參考資料
  • Moriizumi S, et al. (1994) Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1217(2): 199-202.
  • Sanchez D, et al. (2001) Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun. 284(3): 729-37.
  • Boonyasrisawat W, et al. (2002) Analysis of the reg1alpha and reg1beta gene transcripts in patients with fibrocalculous pancreatopathy. Southeast Asian J Trop Med Public Health. 33(2): 365-72.
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