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TRP1 / TYRP1 抗體, 兔多抗

產品資料評論實驗方法
表達宿主: Baculovirus-Insect Cells  
  • Slide 1
13224-H08B-20
13224-H08B-100
20 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
13224-H08H-50
13224-H08H-20
50 µg 
20 µg 
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表達宿主: Baculovirus-Insect Cells  
  • Slide 1
51289-M08B-50
51289-M08B-20
50 µg 
20 µg 
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TRP1 / TYRP1 antibody 研究背景

Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

 TRP1 / TYRP1 antibody 參考資料
  • Sarangarajan R, et al. (2001) Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 14(6): 437-44.
  • Box NF, et al. (1998) Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. Genome. 9 (1): 50-3.
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