Text Size:AAA

EGFL7 / VE-statin 抗體, 兔多抗

產品資料評論實驗方法
描述: Active  
表達宿主: Baculovirus-Insect Cells  
  • Slide 1
11979-H07B-5
11979-H07B-20
11979-H07B-100
5 µg 
20 µg 
100 µg 
Add to Cart
描述: Active  
表達宿主: Baculovirus-Insect Cells  
  • Slide 1
50472-M07B-5
50472-M07B-20
50472-M07B-100
5 µg 
20 µg 
100 µg 
Add to Cart

VE-statin/EGFL7 AntibodyRelated Products

Related Products

Featured Reagent Products

VE-statin/EGFL7 antibody 研究背景

Epidermal growth factor-like protein 7, also known as EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, Vascular endothelial statin, NOTCH4-like protein and EGFL7, is a secreted protein which contains two EGF-like domains and one EMI domain. EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells (ECs). EGFL7 is described as a novel endothelial cell-derived factor involved in the regulation of the spatial arrangement of cells during vascular tube assembly. With its impact on tubulogenesis and vessel shape EGFL7 joined the large family of molecules governing blood vessel formation. EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascular tubulogenesis. EGFL7 is tightly associated with the extracellular matrix (ECM), and it supports EC migration either as a single factor or in combination with other ECM molecules. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. Our study indicates that the molecular composition of the ECM influences vascular morphogenesis. EGFL7 also regulates vascular tubulogenesis. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate.

小鼠 VE-statin/EGFL7 antibody 參考資料
  • Fitch,M.J. et al., 2004, Dev Dyn. 230 (2):316-24.
  • Schmidt,M. et al., 2007, Novartis Found Symp. 283 :18-28.
  • Campagnolo,L.et al., 2008, Gene Expr Patterns  8 (6):389-96.
  • Picuric,S. et al., 2009, Protein Expr Purif. 68 (1):1-6.
  • Nikolic,I. et al., 2010, J Angiogenes Res. 2 (1): 9. 
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”