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FSTL1 抗體, 兔多抗

產品資料評論實驗方法
表達宿主: Human Cells  
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80885-H08H-50
80885-H08H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
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10924-H08H-50
10924-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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51127-M08H-50
51127-M08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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51127-M02H-50
51127-M02H-100
50 µg 
100 µg 
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FSTL1 antibody 研究背景

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

小鼠 FSTL1 antibody 參考資料
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
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