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Syndecan-1 / SDC1 / CD138 抗體, 兔多抗

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
11429-H08H-50
11429-H08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
  • Slide 1
50641-M08H-50
50641-M08H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
80344-R02H-50
80344-R02H-100
50 µg 
100 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
80344-R08H-50
80344-R08H-100
50 µg 
100 µg 
Add to Cart

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Syndecan-1/CD138/SDC1 antibody 研究背景

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

 Syndecan-1/CD138/SDC1 antibody 參考資料
  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”