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Tryptophan Hydroxylase 1 / TPH1 抗體, 兔多抗


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Tryptophan Hydroxylase 1/TPH1 antibody 研究背景

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

 Tryptophan Hydroxylase 1/TPH1 antibody 參考資料
  • Antonia S. New, et al.,1998, American Journal of Medical Genetics Part B. 81 (1): 13-17.
  • Y. C Wang, et al.,2001, Neuropsychobiology. 43 (1): 1 - 4.
  • Diego J. et al., 2003, Science. 299 (5603): 76.
  • Allen NC, et al.,2008, Nat Genet. 40 (7): 827-34.
  • Galfalvy,H. et al., 2009, J Affect Disord. 115 (3):331-8.
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