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人 Prolactin Receptor 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤

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表達宿主: Human Cells  
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10278-H08H-50
10278-H08H-100
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表達宿主: Human Cells  
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50457-M08H-50
50457-M08H-100
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表達宿主: Human Cells  
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50457-M03H-50
50457-M03H-100
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表達宿主: Human Cells  
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80062-R08H-50
80062-R08H-100
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反應性: Human  
應用 : FCM  
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10278-R204-P-25
10278-R204-P-100
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反應性: Human  
應用 : ELISA  
    10278-RP01-50
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    反應性: Human  
    應用 : ELISA  
      10278-MM13-50
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      反應性: Human  
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        10278-R313-50
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        10278-R313-1
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        反應性: Human  
        應用 : ELISA  FCM  IF  ICC/IF  
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        • Slide 1
        10278-R204-50
        10278-R204-100
        10278-R204-1
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        100 µg 
        1 mg 
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        反應性: Human  
        應用 : ELISA  
          10278-RP02-400
          10278-RP02-200
          10278-RP02-100
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          200 µg 
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          反應性: Human  
          應用 : FCM  
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          10278-R204-A-25
          10278-R204-A-100
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          100 Tests 
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          反應性: Rat  
          應用 : ELISA  
            80062-RP01-400
            80062-RP01-200
            80062-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            反應性: Rat  
            應用 : ELISA  
              80062-R113-50
              80062-R113-100
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              反應性: Rat  
              應用 : ELISA  
                80062-T16-50
                80062-T16-200
                80062-T16-100
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                反應性: Rat  
                應用 : ELISA  
                  80062-R001-50
                  80062-R001-100
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                  100 µg 
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                  Prolactin Receptor cdna-clone 研究背景

                  Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type â…  cytokine receptor superfamily, and contains two fibronectin type-â…¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.

                   Prolactin Receptor cdna-clone 參考資料
                • Bole-Feysot C, et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-68.
                • Goffin V, et al. (1999) From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 15(3-5): 189-201.
                • Li Y, et al. (2006) Stabilization of prolactin receptor in breast cancer cells. Oncogene. 25(13): 1896-902.
                • Shao R, et al. (2008) Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice. Biol Reprod. 79(4): 748-57.
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