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人 NBL1 / DAND1 / DAN 蛋白 (His 標籤)

產品資料評論實驗方法
反應性: Human  
應用 : ELISA  
    10169-RP01-400
    10169-RP01-200
    10169-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反應性: Human  
    應用 : 
      10169-MM06-50
      10169-MM06-200
      10169-MM06-100
      10169-MM06-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      反應性: Human  
      應用 : ELISA  IHC-P  
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      10169-RP02-50
      10169-RP02-200
      10169-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反應性: Human  
      應用 : IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      10169-MM01-50
      10169-MM01-200
      10169-MM01-100
      10169-MM01-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      反應性: Human  
      應用 : ELISA  
        10169-MM05-50
        10169-MM05-200
        10169-MM05-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反應性: Mouse  
        應用 : ELISA  
          50976-T16-50
          50976-T16-200
          50976-T16-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart

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          NBL1/DAND1 protein 研究背景

          The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante and PRDC (protein related to DAN and cereberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in regulation of the entry of cells into the S phase. In addition, DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumour suppressor gene for neuroblastoma.

           NBL1/DAND1 protein 參考資料
        • Ozaki T, et al. (1995) Overexpression of DAN gene product in normal rat fibroblasts causes a retardation of the entry into the S phase. Cancer Res. 55(4): 895-900.
        • Nakamura Y, et al. (1997) A product of DAN, a novel candidate tumour suppressor gene, is secreted into culture medium and suppresses DNA synthesis. Eur J Cancer. 33(12): 1986-90.
        • Ogita J, et al. (2001) Expression of the Dan gene during chicken embryonic development. Mech Dev. 109(2): 363-5.
        • Kim AS, et al. (2003) Expression of the BMP antagonist Dan during murine forebrain development. Brain Res Dev Brain Res. 145(1): 159-62.
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