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小鼠 Raf-1/RAF1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

產品資料評論實驗方法

反應性: Human  
應用 : WB  
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101053-T32-50
101053-T32-200
101053-T32-100
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Raf-1/RAF1 cdna-clone 研究背景

RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

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