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小鼠 IL23R / IL23 Receptor 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤

產品資料評論實驗方法
表達宿主: Human Cells  
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13840-H02H-50
13840-H02H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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80395-R02H-50
80395-R02H-20
50 µg 
20 µg 
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表達宿主: Human Cells  
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80395-R08H-50
80395-R08H-10
50 µg 
10 µg 
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表達宿主: Human Cells  
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90123-C02H-50
90123-C02H-100
50 µg 
100 µg 
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IL23R / IL23 Receptor cdna-clone 研究背景

IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

小鼠 IL23R / IL23 Receptor cdna-clone 參考資料
  • Duerr RH, et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 314(5804):1461-3.
  • Cargill M, et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 80(2):273-90.
  • Dubinsky MC, et al. (2007) IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 13(5):511-5.
  • Tremelling M, et al. (2007) IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology. 132(5):1657-64.
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