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人 CTSZ 蛋白 (His 標籤)

產品資料評論實驗方法
反應性: Human  
應用 : ELISA  
    10159-MM05-50
    10159-MM05-200
    10159-MM05-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反應性: Human  
    應用 : ELISA  IHC-P  
    • Slide 1
    10159-T24-50
    10159-T24-200
    10159-T24-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反應性: Mouse  
    應用 : ELISA  
      50089-R009-50
      50089-R009-100
      50 µg 
      100 µg 
      Add to Cart
      反應性: Mouse  
      應用 : ELISA  
        50089-T16-50
        50089-T16-200
        50089-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        CTSZ / CTSX / Cathepsin Z protein 研究背景

        Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression.

         CTSZ / CTSX / Cathepsin Z protein 參考資料
      • Santamara I, et al. (1998) Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J Biol Chem. 273(27): 16816-23.
      • Kos J, et al. (2009) The role of cathepsin X in cell signaling. Cell Adh Migr. 3(2): 164-6.
      • Sevenich L, et al. (2010) Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 107(6): 2497-502.
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