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小鼠 TRACP/ACP5 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

產品資料評論實驗方法
表達宿主: Human Cells  
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10550-H08H-20
10550-H08H-10
20 µg 
10 µg 
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描述: Active  
表達宿主: Human Cells  
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50274-M08H-20
50274-M08H-10
20 µg 
10 µg 
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反應性: Human  
應用 : IHC-P  
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10550-T08-50
10550-T08-200
10550-T08-100
50 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : ELISA  
    10550-T16-50
    10550-T16-200
    10550-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反應性: Human  
    應用 : WB  
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    100741-T32-50
    100741-T32-200
    100741-T32-100
    50 µg 
    200 µg 
    100 µg 
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    TRACP/ACP5 cdna-clone 研究背景

    Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone resorption sites, and, once there, TRACP is believed to initiate osteoblast differentiation, activation, and proliferation. TRACP once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread occurrence with functions in both the skeleton and the immune system. Two forms of TRACP circulate in human blood, TRACP 5a derived from macrophages and dendritic cells, and TRACP-5b derived from osteoclasts. Recent data have demonstrated the utility of TRACP-5b as a marker of osteoclast number and bone resorption, and serum TRACP-5a as a marker of inflammatory conditions. TRACP is expressed by osteoclasts, macrophages, dendritic cells and a number of other cell types. It has a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone, cytokine production by macrophages and dendritic cells, macrophage recruitment, dendritic cell maturation and a role in the development of Th1 responses.

    小鼠 TRACP/ACP5 cdna-clone 參考資料
  • Hayman AR. (2008) Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy. Autoimmunity. 41(3): 218-23.
  • Halleen JM, et al. (2006) Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption. Clin Lab. 52(9-10): 499-509.
  • Mochizuki Y. (2006) Bone and bone related biochemical examinations. Bone and collagen related metabolites. Tartrate-resistant acid phosphatase (TRACP). Clin Calcium. 16(6): 948-55.
  • Lamp EC, et al. (2000) Biology of tartrate-resistant acid phosphatase. Leuk Lymphoma. 39(5-6): 477-84.
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