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Endoglin / CD105 / ENG 抗體, 兔多抗, 抗原親和純化

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10149-H08H-50
10149-H08H-20
50 µg 
20 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
10149-H02H-50
10149-H02H-20
50 µg 
20 µg 
Add to Cart
描述: Active  
表達宿主: Human Cells  
  • Slide 1
50407-M08H-50
50407-M08H-20
50407-M08H-100
50 µg 
20 µg 
100 µg 
Add to Cart

Endoglin/CD105  ELISA配對抗體

檢測限: 31.25 pg/ml
SEK50407-5
SEK50407-15
5 Plates 
15 Plates 
Add to Cart
檢測限: 31.25 pg/ml
SEK10149-5
SEK10149-15
5 Plates 
15 Plates 
Add to Cart

Endoglin/CD105  AntibodyRelated Products

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Endoglin/CD105  antibody 研究背景

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

 Endoglin/CD105  antibody 參考資料
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