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小鼠 TNFRSF21/DR6 基因全長cDNA ORF克隆 (表達載體), C-His 標籤

產品資料評論實驗方法
表達宿主: Human Cells  
  • Slide 1
10175-HCCH-200
10175-HCCH-100
200 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10175-H08H-200
10175-H08H-100
200 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
  • Slide 1
10175-H02H-200
10175-H02H-100
200 µg 
100 µg 
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表達宿主: Human Cells  
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50263-M08H-50
50263-M08H-100
50 µg 
100 µg 
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表達宿主: Human Cells  
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80155-R02H-50
80155-R02H-200
50 µg 
200 µg 
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表達宿主: Human Cells  
  • Slide 1
90331-C08H-200
90331-C08H-100
200 µg 
100 µg 
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反應性: Human  
應用 : ELISA  
    10175-RP01-400
    10175-RP01-200
    10175-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反應性: Human  
    應用 : ELISA  
      10175-MM03-50
      10175-MM03-200
      10175-MM03-100
      50 µg 
      200 µg 
      100 µg 
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      反應性: Human  
      應用 : ELISA  WB  
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      10175-T48-50
      10175-T48-200
      10175-T48-100
      50 µg 
      200 µg 
      100 µg 
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      反應性: Human  
      應用 : ELISA  
        10175-R001-50
        10175-R001-100
        50 µg 
        100 µg 
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        反應性: Mouse  
        應用 : ELISA  
          50263-RP02-50
          50263-RP02-200
          50263-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反應性: Mouse  
          應用 : ELISA  
            50263-RP01-400
            50263-RP01-200
            50263-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart

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            TNFRSF21/DR6 cdna-clone 研究背景

            TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

            小鼠 TNFRSF21/DR6 cdna-clone 參考資料
          • Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
          • Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
          • Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.
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