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人 Complement Component C2 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤

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描述: Active  
表達宿主: Human Cells  
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10154-H08H-20
10154-H08H-10
20 µg 
10 µg 
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表達宿主: Human Cells  
  • Slide 1
10154-H02H-20
10154-H02H-10
20 µg 
10 µg 
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表達宿主: Human Cells  
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51140-M08H-20
51140-M08H-10
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10 µg 
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反應性: Human  
應用 : 
    10154-MM06-50
    10154-MM06-200
    10154-MM06-100
    10154-MM06-1
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    200 µg 
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    1 mg 
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    反應性: Human  
    應用 : 
      10154-R014-50
      10154-R014-100
      10154-R014-1
      50 µg 
      100 µg 
      1 mg 
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      反應性: Human  
      應用 : ELISA  
        10154-R002-50
        10154-R002-100
        50 µg 
        100 µg 
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        Complement Component C2 cdna-clone 研究背景

        Complement component C2 is part of the classical complement pathway which plays a major role in innate immunity against infection. C2 is a glycoprotein synthesized in liver hepatocytes and several other cell types in extrahepatic tissues. This pathway is triggered by a multimolecular complex C1, and subsequently the single-chain form of C2 is cleaved into two chains referred to C2a and C2b by activated C1. The second component of complement (C2) is a multi-domain serine protease that provides catalytic activity for the C3 and C5 convertases of the classical and lectin pathways of human complement. C4b and C2 was investigated by surface plasmon resonance. C2a containing a serine protease domain combines with complement component C4b to form the C3 convertase C4b2a which is responsible for C3 activation, and leads to the stimulation of adaptive immune responses via Lectin pathway. C2 bound to C4b is cleaved by classical (C1s) or lectin (MASP2) proteases to produce C4bC2a. C2 has the same serine protease domain as C4bC2a but in an inactive zymogen-like conformation, requiring cofactor-induced conformational change for activity. Deficiency of C2 (C2D) is the most common genetic deficiency of the complement system, and two types of C2D have been recognized in the context of specific MHC haplotypes. C2D in human is reported to increase susceptibility to infection, and is associated with certain autoimmune diseases, such as rheumatological disorders.

         Complement Component C2 cdna-clone 參考資料
      • Laich A, et al. (2002) Complement C4bC2 complex formation: an investigation by surface plasmon resonance. Biochim Biophys Acta. 1544(1-2): 96-112.
      • Halili MA, et al. (2009) Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation. Biochemistry. 48(35): 8466-72.
      • Krishnan V, et al. (2009) The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation. Acta Crystallogr D Biol Crystallogr. 65(Pt 3): 266-74.
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