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人 IL1R2 / IL1RB / CD121b 蛋白 (His 標籤)

產品資料評論實驗方法
反應性: Human  
應用 : ELISA  
    10111-RP02-50
    10111-RP02-200
    10111-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反應性: Human  
    應用 : ELISA  
      10111-MM11-50
      10111-MM11-200
      10111-MM11-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反應性: Human  
      應用 : ELISA  
        10111-RP01-400
        10111-RP01-200
        10111-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        反應性: Human  
        應用 : ELISA  
          10111-R020-50
          10111-R020-100
          50 µg 
          100 µg 
          Add to Cart
          反應性: Human  
          應用 : ELISA  
            10111-MM04-50
            10111-MM04-200
            10111-MM04-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反應性: Human  
            應用 : 
              10111-MM02-50
              10111-MM02-200
              10111-MM02-100
              10111-MM02-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
              Add to Cart
              反應性: Human  
              應用 : 
                10111-R041-50
                10111-R041-100
                10111-R041-1
                50 µg 
                100 µg 
                1 mg 
                Add to Cart
                反應性: Mouse  
                應用 : ELISA  
                  51090-RP01-400
                  51090-RP01-200
                  51090-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反應性: Mouse  
                  應用 : ELISA  
                    51090-T16-50
                    51090-T16-200
                    51090-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    反應性: Rat  
                    應用 : 
                      80196-R161-50
                      80196-R161-100
                      80196-R161-1
                      50 µg 
                      100 µg 
                      1 mg 
                      Add to Cart
                      反應性: Rat  
                      應用 : ELISA  
                        80196-MM05-50
                        80196-MM05-200
                        80196-MM05-100
                        80196-MM05-1
                        50 µg 
                        200 µg 
                        100 µg 
                        1 mg 
                        Add to Cart
                        反應性: Rat  
                        應用 : ELISA  
                          80196-RP01-400
                          80196-RP01-200
                          80196-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
                          Add to Cart
                          反應性: Rat  
                          應用 : ELISA  
                            80196-R021-50
                            80196-R021-100
                            50 µg 
                            100 µg 
                            Add to Cart

                            IL-1R2/CD121b ELISA配對抗體

                            檢測限:
                            SEK80196-5
                            SEK80196-15
                            5 Plates 
                            15 Plates 
                            Add to Cart
                            檢測限: 9.375 pg/ml
                            SEK10111-5
                            SEK10111-15
                            5 Plates 
                            15 Plates 
                            Add to Cart

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                            IL-1R2/CD121b protein 研究背景

                            Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

                             IL-1R2/CD121b protein 參考資料
                          • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
                          • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
                          • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
                          • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”