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小鼠 GAPDH 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤

產品資料評論實驗方法
表達宿主: E. coli  
  • Slide 1
10094-H07E-50
10094-H07E-100
50 µg 
100 µg 
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表達宿主: E. coli  
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51221-M07E-20
51221-M07E-100
20 µg 
100 µg 
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反應性: Human  
應用 : IHC-P  
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100242-R005-50
100242-R005-100
50 µg 
100 µg 
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反應性: Human  
應用 : ELISA  WB  IP  
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  • Slide 1
10094-T52-50
10094-T52-200
10094-T52-100
50 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : WB  
  • Slide 1
100242-MM05-50
100242-MM05-100
50 µg 
100 µg 
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反應性: Human  
應用 : WB  IHC-P  
  • Slide 1
  • Slide 1
  • Slide 1
100242-T40-50
100242-T40-100
50 µg 
100 µg 
Add to Cart
反應性: Human  
應用 : IHC-P  
  • Slide 1
  • Slide 1
100242-T08-50
100242-T08-100
50 µg 
100 µg 
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GAPDH cdna-clone 研究背景

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.

小鼠 GAPDH cdna-clone 參考資料
  • Hara MR, et al. (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. PNA. 103 (10): 3887-9.
  • Hara MR, et al. (2006) GAPDH as a sensor of NO stress.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (5): 502-9.
  • Tarze A, et al. (2007) GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilizationGAPDH and apoptosis. Oncogene. 26: 2606-20.
  • Yi MK, et al. (2000) Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function. Journal of Virology. 74 (14) : 6459-68.
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