CD46: CD46 Protein | CD46 Antibody

CD46 Gene family

CD46 Background

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.

Reference for CD46

  • Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
  • Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
  • Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.

CD46 Protein

CD46 protein function

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.; (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {ECO:0000269|PubMed:12915534, ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, ECO:0000269|PubMed:16254377}.; (Microbial infection) Acts as a receptor for cultured Measles virus. {ECO:0000269|PubMed:10972291}.; (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {ECO:0000269|PubMed:12663806, ECO:0000269|PubMed:12724329}.; (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

CD46 protein expression

Tissue specificity

Expressed by all cells except erythrocytes.

CD46 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CD46 Antibody

There are 7 CD46 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, FCM, ICC/IF, WB, IP. There are 3 CD46 antibody for ELISA, 3 CD46 antibody for IHC-P, 4 CD46 antibody for FCM, 2 CD46 antibody for ICC/IF, 1 CD46 antibody for WB, 1 CD46 antibody for IP. Among all these CD46 antibodies, there are 5 anti-CD46 mouse monoclonal antibodies , 1 anti-CD46 rabbit monoclonal antibodies , 1 anti-CD46 rabbit polyclonal antibodies . All the CD46 anbodies are produced in house and all are in stock. CD46 antibody customerized service is available.

CD46 Gene

CD46 gene / cDNA is a protein-coding gene which located on 1q32.2. The CD46 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.91 organisms have orthologs with human gene CD46.