CD4 cDNA Clone: Expression and Clone Vector / Plasmid

CD4 cDNA / Gene Overview

CD4 gene / cDNA is a protein-coding gene which located on 12p13.31. The CD4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.152 organisms have orthologs with human gene CD4.

CD4 cDNA / Gene Function

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

CD4 cDNA / Gene Sequence

LOCUS
LOCUS NM_000616 3134 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens CD4 molecule (CD4), transcript variant 1, mRNA.
ACCESSION
NM_000616
VERSION
NM_000616.4

This sequence information is just for reference only.

CD4 Family & Reagents

CD4 Gene family reagents (CD molecules)

Approved Symbol Reagent list
TNFRSF8
CD244
CEACAM3
CD8A
LAIR2
CD300E
KIR2DL5A
GYPA
CD160
CDH2
Approved Symbol Reagent list
TLR4
CD3D
ICOSLG
TNFRSF18
IL3Ra
F11R
LAG3
TLR2
HAVCR1
MPL

CD4 Gene family reagents (V-set domain containing)

Approved Symbol Reagent list
CD8B
TREM2
CTLA4
TIGIT
SIGLEC15
CEACAM5
CD80
VTCN1
HHLA2
HAPLN1
Approved Symbol Reagent list
HAVCR2
SIGLEC10
CD300C
CXADR
ICOSLG
BTN3A1
TIMD4
PILRA
PSG6
CADM4

CD4 Gene family reagents (C2-set domain containing)

Approved Symbol Reagent list
ICOSLG
SIGLEC10
KIRREL3
NECTIN4
KIRREL2
CRTAM
CD22
AGER
CD274
MAG
Approved Symbol Reagent list
BTN3A1
CD200R1
VCAM1
CD80
BCAM
CD276
TMEM25
KIRREL1
CADM1
ALCAM

CD4 cDNA / Gene Expression

Broad expression in spleen (RPKM 82.4), lymph node (RPKM 55.1) and 19 other tissues

Recombinant CD4 protein citations

Title
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
Year
2014
Author
M Bonsignori, K Wiehe, SK Grimm…
Journal
The Journal of Clinical Investigation
Title
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
Year
2014
Author
M Bonsignori, K Wiehe, SK Grimm…
Journal
The Journal of Clinical Investigation
Title
Stockpiled pre-pandemic H5N1 influenza virus vaccines with AS03 adjuvant provide cross-protection from H5N2 clade 2.3.4.4 virus challenge in ferrets
Year
2017
Author
Sun, X;Belser, JA;Pulit-Penaloza, JA;Creager, HM;Guo, Z;Jefferson, SN;Liu, F;York, IA;Stevens, J;Maines, TR;Jernigan, DB;Katz, JM;Levine, MZ;Tumpey, TM;
Journal
Virology
Title
The immune correlates of protection for an avian influenza H5N1 vaccine in the ferret model using oil-in-water adjuvants
Year
2017
Author
Wong, SS;Duan, S;DeBeauchamp, J;Zanin, M;Kercher, L;Sonnberg, S;Fabrizio, T;Jeevan, T;Crumpton, JC;Oshansky, C;Sun, Y;Tang, L;Thomas, P;Webby, R;
Journal
Sci Rep
Title
Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model
Year
2018
Author
Reber, AJ;Music, N;Kim, JH;Gansebom, S;Chen, J;York, I;
Journal
Sci Rep
Title
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Year
2018
Author
Tauriello, DVF;Palomo-Ponce, S;Stork, D;Berenguer-Llergo, A;Badia-Ramentol, J;Iglesias, M;Sevillano, M;Ibiza, S;Cañellas, A;Hernando-Momblona, X;Byrom, D;Matarin, JA;Calon, A;Rivas, EI;Nebreda, AR;Riera, A;Attolini, CS;Batlle, E;
Journal
Nature
Title
The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms
Year
2018
Author
Balbinot, C;Armant, O;Elarouci, N;Marisa, L;Martin, E;De Clara, E;Onea, A;Deschamps, J;Beck, F;Freund, JN;Duluc, I;
Journal
J. Exp. Med.