CD4 cDNA Clone: Expression and Clone Vector / Plasmid
CD4 cDNA / Gene Overview
CD4 gene / cDNA is a protein-coding gene which located on 12p13.31. The CD4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.152 organisms have orthologs with human gene CD4.
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
CD4 cDNA / Gene Sequence
LOCUS NM_000616 3134 bp mRNA linear PRI 24-JUN-2018
Homo sapiens CD4 molecule (CD4), transcript variant 1, mRNA.
This sequence information is just for reference only.
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