Anti-CD31 Antibody

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Anti-CD31 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-CD31 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CD31
No cross-reactivity in ELISA with
Human ICAM1
Human ICAM2
Human ICAM3
Human VCAM1/CD106
Mouse VCAM1/CD106
Immunogen
Recombinant Human CD31 / PECAM1 protein (Catalog#10148-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD31 / PECAM1 (rh CD31 / PECAM1; Catalog#10148-H08H; EAW94208.1; Met 1-Lys 601).
Source
Monoclonal Rabbit IgG Clone #078
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD31 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD31 Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of human CD31 in human mesenteric tumor with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to vascular endothelial cells.
Immunochemical staining of human CD31 in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to vascular endothelial cells.

Anti-CD31 Antibody: Alternative Names

Anti-CD31 Antibody; Anti-CD31/EndoCAM Antibody; Anti-endoCAM Antibody; Anti-GPIIA' Antibody; Anti-PECA1 Antibody; Anti-PECAM-1 Antibody

CD31 Background Information

The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 13-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. CD31 protein is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies. CD31 plays a key role in removing aged neutrophils and tissue regeneration. CD31 protein mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development.
Full Name
platelet/endothelial cell adhesion molecule 1
References
  • Deaglio S, et al. (2000) CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes. Chem Immunol. 75: 99-120.
  • Kohler S, et al. (2009) Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood. 113(4): 769-74.
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