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CD266 & CD155 Immune Checkpoint Pathway

CD266 & CD155 Immune Checkpoint Pathway: Description

CD155 / PVR is a glycoprotein composed of two Ig-like C2-type domains and one Ig-like V-type domain that is necessary for poliovirus binding and uptake. CD155 / PVR is a broadly expressed receptor that can interact with several ligands, such as CD226 / DNAM-1, TIGIT, CD96, vitronectin, integrin αvβ3, and PDGFR. The functions of CD155 / PVR include roles in cell adhesion, neural differentiation, and NK cell effector functions.
CD226 (also known as DNAM-1) is a glycoprotein belonging to the Ig superfamily that is expressed on the surface of NK cells, platelets, monocytes, and activated CD4+ T cells. CD226 / DNAM-1 binds to CD155 / PVR and CD112, both expressed on APCs, but only CD155 / PVR is induced in T cells upon their activation. CD226 / DNAM-1 mediates cellular adhesion and triggers NK cell effector functions. In human CD4+ T cells, CD266 & CD155 immune checkpoint pathway associates with LFA-1 and contributes to LFA-1 costimulatory signals that promote Th1 cell differentiation. CD226 / DNAM-1 allelic variants have been defined as a genetic risk factor for developing MS and T1D. This disease-associated single-nucleotide polymorphism is located in the coding region and generates an amino acid change Ser307Gly in the intracellular domain. Although these genomic data identify molecules involved in autoimmunity in an unbiased manner, the functional role of CD226 / DNAM-1 in human autoimmune diseases has not been defined.

CD266 & CD155 Immune Checkpoint Pathway: Reference

Ester Lozano et al. The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans. The Journal of Immunology. 2013; 191: 3673-3680

CD266 & CD155 Immune Checkpoint Pathway: Relatives

Co-inhibitory immune checkpoint pathways Co-stimulatory immune checkpoint pathways
PD1 & PD-L1 immune checkpoint pathway CD40 & CD40L immune checkpoint pathway
CTLA-4 & CD80 (CD86) immune checkpoint pathway OX40 & OX40L immune checkpoint pathway
B7-H3 / CD276 immune checkpoint pathway HVEM & LIGHT immune checkpoint pathway
B7-H4 / B7S1 / B7x immune checkpoint pathway CD28 & CD80 (CD86) immune checkpoint pathway
HVEM & BTLA immune checkpoint pathway GITR & GITR Ligand immune checkpoint pathway
HVEM & CD160 immune checkpoint pathway CD27 & CD70 immune checkpoint pathway
LAG3 / CD223 / Lymphocyte activation gene 3 immune checkpoint pathway 4-1BB & 4-1BBL immune checkpoint pathway
Galectin-9 & TIM-3 immune checkpoint pathway ICOS & ICOS Ligand immune checkpoint pathway
Indoleamine 2,3-dioxygenase/IDO immune checkpoint pathway  
VISTA / B7-H5 / GI24 immune checkpoint pathway  
CEACAM1 / CD66a immune checkpoint pathway  
SIRP alpha & CD47 immune checkpoint pathway  
2B4 & CD48 immune checkpoint pathway  
TIGIT & CD155 immune checkpoint pathway  
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