BCAM: BCAM Protein | BCAM Antibody

BCAM Gene family

BCAM Background

The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

Reference for BCAM

  • Kikkawa Y, et al. (2005) Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res. 46 (4-5): 193-9.
  • El Nemer W, et al. (2007) Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. Blood. 109 (8): 3544-51.
  • Colin Y, et al. (2008) Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 15 (6): 402-5.
  • El Nemer W, et al. (2008) Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. Transfus Clin Biol. 15 (1-2): 29-33.

BCAM Protein

BCAM protein function

Laminin alpha-5 receptor. May mediate intracellular signaling. {ECO:0000269|PubMed:9616226}.

BCAM protein expression

Tissue specificity

Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

Induction

Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.

BCAM protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    628.00
  • Mass (Da)
    67.00

BCAM Antibody

There are 8 BCAM antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA, ELISA(Det), WB, IHC-P, IP. There are 1 BCAM antibody for ELISA(Cap), 6 BCAM antibody for ELISA, 1 BCAM antibody for ELISA(Det), 1 BCAM antibody for WB, 3 BCAM antibody for IHC-P, 1 BCAM antibody for IP. Among all these BCAM antibodies, there are 1 anti-BCAM mouse monoclonal antibodies , 3 anti-BCAM rabbit monoclonal antibodies , 4 anti-BCAM rabbit polyclonal antibodies . All the BCAM anbodies are produced in house and all are in stock. BCAM antibody customerized service is available.

BCAM Gene

BCAM gene / cDNA is a protein-coding gene which located on 19q13.32. The BCAM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.138 organisms have orthologs with human gene BCAM.