CD226: CD226 Protein | CD226 Antibody

CD226 Gene family

CD226 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.

CD226 Protein

CD226 protein function

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:8673704}.

CD226 protein expression

Tissue specificity

Expressed by peripheral blood T-lymphocytes.

CD226 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    336.00
  • Mass (Da)
    38.00

CD226 Antibody

There are 11 CD226 antibodies which are validated in multiple tissues with various applications, including ELISA, FCM. There are 8 CD226 antibody for ELISA, 4 CD226 antibody for FCM. Among all these CD226 antibodies, there are 5 anti-CD226 rabbit monoclonal antibodies , 6 anti-CD226 rabbit polyclonal antibodies . All the CD226 anbodies are produced in house and all are in stock. CD226 antibody customerized service is available.

CD226 Gene

CD226 gene / cDNA is a protein-coding gene which located on 18q22.2. The CD226 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.213 organisms have orthologs with human gene CD226.