CD18 cDNA Clone: Expression and Clone Vector / Plasmid

CD18 cDNA / Gene Overview

ITGB2 gene / cDNA is a protein-coding gene which located on 21q22.3. The ITGB2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.195 organisms have orthologs with human gene ITGB2.

CD18 cDNA / Gene Function

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

CD18 cDNA / Gene Sequence

LOCUS
LOCUS NM_000211 2973 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens integrin subunit beta 2 (ITGB2), transcript variant 1, mRNA.
ACCESSION
NM_000211
VERSION
NM_000211.4

This sequence information is just for reference only.

CD18 Family & Reagents

CD18 Gene family reagents (CD molecules)

Approved Symbol Reagent list
TNFSF4
TLR2
CD68
FZD10
Clec9a
CD207
GP1BB
NECTIN3
CDH2
LY9
Approved Symbol Reagent list
IGF1R
SELL
BCAM
ENPP3
HAVCR1
CD209
LAIR2
TNFRSF10C
FAS
CD3D

CD18 Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C5
C7
CD59
CFD
CFHR1
CR2
Approved Symbol Reagent list
C2
C6
CD46
CFB
CFH
CFHR2
   

CD18 Gene family reagents (Integrin beta subunits)

Approved Symbol Reagent list
ITGB1

CD18 cDNA / Gene Alias

  • complement component 3 receptor 3 and 4 subunit
  • LFA-1
  • MAC-1

CD18 cDNA / Gene Expression

Broad expression in bone marrow (RPKM 117.8), appendix (RPKM 80.8) and 14 other tissues