C2 Protein

C2 Protein Overview

C2 reagents

A number sign (#) is used with this entry because complement component-2 deficiency is caused by homozygous or compound heterozygous mutation in the C2 gene (613927).

C2 protein family

Belongs to the peptidase S1 family.

C2 protein name

Recommended name
Complement C2
Alternative name
C3/C5 convertase Complement C2b fragment Complement C2a fragment

C2 Protein Sequence

Species Human C2 protein
Length 752
Mass (Da) 83268
Sequence Human C2 protein sequence
Species Mouse C2 protein
Length 760
Mass (Da) 84741
Sequence Mouse C2 protein sequence
Species
Length
Mass (Da)
Sequence

C2 Protein Molecular Weight & PI

Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-752 Complement C2.

Molecular weight (Da)

81085.11

Theoretical pI

7.57

C2 Protein Structure

Complement component C2a
Deposited
2006-08-29   Released:  2006-10-17
Deposition Author(s)
Milder, F.J., Raaijmakers, H.C.A., Vandeputte, D.A.A., Schouten, A., Huizinga, E.G., Romijn, R.A., Hemrika, W., Roos, A., Daha, M.R., Gros, P.
Organism(s)
Homo sapiens
Expression System
Mesocricetus auratus
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.1000 Å
R-Value Free
0.240
R-Value Work
0.189
2I6Q From PDB

Human C2 protein Secondary structure

C2 Protein Interaction

Recombinant C2 Protein Feature

C2 Protein, Mouse, Recombinant (His Tag)

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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