C2 cDNA Clone: Expression and Clone Vector / Plasmid

C2 cDNA / Gene Overview

C2 gene / cDNA is a protein-coding gene which located on 6p21.33. The C2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.113 organisms have orthologs with human gene C2.

C2 cDNA / Gene Function

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

C2 cDNA / Gene Sequence

LOCUS
LOCUS NM_000063 2862 bp mRNA linear PRI 30-JUN-2018
DEFINITION
Homo sapiens complement C2 (C2), transcript variant 1, mRNA.
ACCESSION
NM_000063
VERSION
NM_000063.5

This sequence information is just for reference only.

C2 Family & Reagents

C2 Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C6
CD46
CFB
CFH
CFHR2
Approved Symbol Reagent list
C5
C7
CD59
CFD
CFHR1
CR2

C2 Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
APOH
C7
CD55
CFH
CFHR2
F13B
IL2RA
SELE
SELP
SUSD4
Approved Symbol Reagent list
C6
CD46
CFB
CFHR1
CR2
HP
PAPPA2
SELL
SEZ6L2
TPO

C2 cDNA / Gene Expression

Biased expression in liver (RPKM 95.8), lung (RPKM 36.7) and 11 other tissues

Recombinant C2 protein citations

Title
Complement C2
Year
2013
Author
Reddy Dinasarapu, A;Chandrasekhar, A;
Journal
UCSD Molecule Pages
Title
Characterization of Schistosoma japonicum tetraspanning orphan receptor and its role in binding to complement C2 and immunoprotection against murine schistosomiasis
Year
2017
Author
Ma, S;Zai, J;Han, Y;Hong, Y;Zhang, M;Cao, X;Han, Q;Lu, K;Zhao, Z;Lin, J;Fu, Z;
Journal
Parasit Vectors
Title
Characterization of Schistosoma japonicum tetraspanning orphan receptor and its role in binding to complement C2 and immunoprotection against murine schistosomiasis
Year
2017
Author
Ma, S;Zai, J;Han, Y;Hong, Y;Zhang, M;Cao, X;Han, Q;Lu, K;Zhao, Z;Lin, J;Fu, Z;
Journal
Parasit Vectors