C1s Protein

C1s Protein Overview

C1s reagents

MacKinnon et al. (1987) derived the complete amino acid sequence of C1s from molecular cloning of cDNA. Tosi et al. (1987) presented the complete cDNA sequence of C1s. Kusumoto et al. (1988) found that the amino acid sequence of C1s was 40.5% identical to that of C1r (216950), with excellent matches of tentative disulfide bond locations conserving the overall domain structure of C1r.

C1s protein family

Belongs to the peptidase S1 family.

C1s protein name

Recommended name
Complement C1s subcomponent
Alternative name
C1 esterase Complement component 1 subcomponent s

C1s Protein Sequence

Species Human C1s protein
Length 688
Mass (Da) 76684
Sequence Human C1s protein sequence
Mass (Da)
Species Rat C1s protein
Length 688
Mass (Da) 77071
Sequence Rat C1s protein sequence

C1s Protein Molecular Weight & PI

Complement C1s subcomponent precursor (EC (C1 esterase) (Complement component 1 subcomponent s) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 16-688 Complement C1s subcomponent.

Molecular weight (Da)


Theoretical pI


C1s Protein Structure

2013-07-10   Released:  2013-08-07
Deposition Author(s)
Wallis, R., Venkatraman Girija, U., Moody, P.C.E., Marshall, J.E.
Homo sapiens
Expression System
Experimental Data Snapshot
2.9210 Å
R-Value Free
R-Value Work

Human C1s protein Secondary structure

C1s Protein Interaction

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