BRAF Targeted Therapy

BRAF Targeted Therapy: Introduction

BRAF belongs to a family of serine-threonine protein kinases that includes ARAF, BRAF, and CRAF (RAF1). RAF kinases are central mediators in the MAP kinase signaling cascade and exert their effect predominantly through phosphorylation and activation of MEK. This occurs following the dimerization (hetero- or homo-) of the RAF molecules. As part of the MAP kinase pathway, RAF is involved in many cellular processes, including cell proliferation, differentiation, and transcriptional regulation.

BRAF Targeted Therapy: Melanoma

BRAF is a serine/threonine protein kinase activating the MAP kinase/ERK-signaling pathway. About 50 % of melanomas harbors activating BRAF mutations (over 90 % V600E). BRAFV600E has been implicated in different mechanisms underlying melanomagenesis, most of which due to the deregulated activation of the downstream MEK/ERK effectors.

BRAF Targeted Therapy: Lung Cancer

Somatic activating BRAF mutations were first described by Davies et al. in 2002. Genomic DNA from 545 cancer cell lines and the corresponding matched lymphoblastoid cell lines from the same individuals were screened for sequence variants through the coding exons and intron-exon junctions of the BRAF gene. They reported an incidence of 8% across all cancers (43/545) and 3% in lung cancer (all adenocarcinomas) (4/131) . All BRAF somatic mutations found in the cancer lines were in exons 11 and 15. RAS and BRAF mutations usually occur in the same cancer types, but these mutations are found in a mutually exclusive fashion.

Targeted Therapy
What is Targeted Therapy
Targeted Therapy: Targets
Targeted Therapy for Cancer
Targeted Therapy for Kidney Cancer
Targeted Therapy for Liver Cancer
Colorectal Cancer Targeted Therapy
What is Targeted Therapy for Cancer
Targeted Therapy for Leukemia
Targeted Therapy for Pancreatic Cancer
Prostate Cancer Targeted Therapy
Targeted Therapy for Ovarian Cancer
Melanoma Targeted Therapy
Targeted Therapy for Lung Cancer
Targeted Therapy for Breast Cancer
EGFR Targeted Therapy
EGFR Targeted Therapy for Breast Cancer
EGFR Targeted Therapy for Colorectal Cancer
EGFR Targeted Therapy for Head and Neck Cancer
EGFR Targeted Therapy for Non-Small-Cell Lung Cancer
EGFR Targeted Therapy for Ovarian Cancer
EGFR Targeted Therapy for Pancreatic Cancer
HER2 Targeted Therapy
HER2 Targeted Therapy for Breast Cancer
HER2 Targeted Therapy for Colorectal Cancer
Her2 targeted therapy for Ovarian cancer
VEGF Targeted Therapy
VEGF Targeted Therapy for Breast Cancer
VEGF Targeted Therapy for Lung Cancer
VEGF Targeted Therapy for Prostate Cancer
VEGF Targeted Therapy for Colorectal Cancer
BRAF Targeted Therapy
BRAF Targeted Therapy for Melanoma
BRAF Targeted Therapy for Lung Cancer
ALK Targeted Therapy
ALK Targeted Therapy for Lung Cancer
ALK Targeted Therapy for Anaplastic Large Cell Lymphoma
Immune Checkpoint Targeted Therapy
Targeted Therapy Drugs
Targeted Therapy Drugs: Elotuzumab
Targeted Therapy Drugs: Necitumumab
Targeted Therapy Drugs: Daratumumab
Targeted Therapy Drugs: Ramucirumab
Targeted Therapy Drugs: Trastuzumab
Targeted Therapy Drugs: Vemurafenib
Targeted Therapy Drugs: Crizotinib
The Differences between Chemotherapy and Targeted Therapy
Side Effects of Targeted Therapy
Oral Targeted Therapy
Targeted Therapy Resistance
How does Targeted Therapy Work