Autoimmune Disease Immunotherapy Related Molecules

Autoimmune Disease Immunotherapy Related Molecules

TNF-a ICOS CD3 GAD65 Insulin Hsp60
S1P CD52 CD25 (IFN)-β TLR3 CD22
CD40L CD86 CD80 CD20 A3AR CD28
LFA-1 p75 PPAR CTLA-4 IL-23 IL-17
IL-1 VCAM1 CD2 B-lymphocyte stimulator protein (BLyS)    

Autoimmune Disease Immunotherapy Related Molecules: HSP60

HSP60 Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. some new research has indicated that HSP60 possibly plays a role in a "danger signal cascade" immune response. There is also mounting evidence that it plays a role in autoimmune disease.

Autoimmune Disease Immunotherapy Related Molecules: GAD65

GAD65 is the product of a gene located on Chromosome 10 with containing 585 aminoacids. In T1D autoimmunity, only GAD65 is antigenic despite the higher expression of GAD67 in islet beta cells. Interestingly, in stiff man syndrome, the other well documented case of GAD antigenicity, GAD65 is also the major autoantigen. The differences in the antigenicity of the GAD isoforms merits scrutiny, particularly in view of the potential of GAD 65 to be used in immunotherapies.

Autoimmune Disease Immunotherapy Related Molecules: Reference

Towns R et al. GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA). Drugs of the future. 2011;36(11):847.
Hansen JJ et al. (January 2003). "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter". Hum. Genet. 112 (1): 71–7.

What is Immunotherapy
Cancer Immunotherapy
Allergy Immunotherapy
Autoimmune Diseases Immunotherapy
Immunotherapy for Autoimmune Diseases: Rheumatoid Arthritis
Immunotherapy for Autoimmune Diseases: Type 1 Diabetes
Immunotherapy for Autoimmune Diseases: Multiple Sclerosis
Immunotherapy for Autoimmune Diseases: Psoriasis
Immunotherapy for Autoimmune Diseases: Systemic Lupus Erythematosus
Autoimmune Disease Immunotherapy Related Molecules
Immunotherapy Related Molecules
Sublingual Immunotherapy
Side Effects of Immunotherapy
Immunotherapy Drugs
Adoptive Immunotherapy
Journal of Immunotherapy
Immunotherapy Conference