ACVR2A cDNA Clone: Expression and Clone Vector / Plasmid

ACVR2A cDNA / Gene Overview

ACVR2A gene / cDNA is a protein-coding gene which located on 2q22.3-q23.1. The ACVR2A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.229 organisms have orthologs with human gene ACVR2A.

ACVR2A cDNA / Gene Function

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

ACVR2A cDNA / Gene Sequence

LOCUS
LOCUS NM_001616 5263 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.
ACCESSION
NM_001616
VERSION
NM_001616.4

This sequence information is just for reference only.

ACVR2A Family & Reagents

ACVR2A Gene family reagents (Type 2 receptor serine/threonine kinases)

Approved Symbol Reagent list
ACVR2B
TGFBR2
Approved Symbol Reagent list
BMPR2
   

ACVR2A cDNA / Gene Alias

  • ACTRII

ACVR2A cDNA / Gene Expression

Ubiquitous expression in skin (RPKM 13.5), gall bladder (RPKM 6.4) and 25 other tissues

Recombinant ACVR2A protein citations

Title
Updated protocols for the detection of Sotatercept and Luspatercept in human serum
Year
2018
Author
Reichel, C;Gmeiner, G;Walpurgis, K;Thevis, M;
Journal
Drug Test Anal