ACVR2A cDNA Clone: Expression and Clone Vector / Plasmid
ACVR2A cDNA / Gene Overview
ACVR2A gene / cDNA is a protein-coding gene which located on 2q22.3-q23.1. The ACVR2A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.229 organisms have orthologs with human gene ACVR2A.
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
ACVR2A cDNA / Gene Sequence
LOCUS NM_001616 5263 bp mRNA linear PRI 22-JUL-2018
Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA.
This sequence information is just for reference only.
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