ABCB7 cDNA Clone: Expression and Clone Vector / Plasmid

ABCB7 cDNA / Gene Overview

ABCB7 cDNA / gene is a gene with protein product which located on Xq13.3. The ABCB7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog. 234 organisms have orthologs with human gene ABCB7.

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ABCB7 cDNA / Gene Function

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

ABCB7 cDNA / Gene Sequence

AF038950 2384 bp mRNA linear HTC 22-MAY-2001
Homo sapiens ATP binding cassette transporter mRNA, complete cds.

This sequence information is just for reference only.

ABCB7 cDNA / Gene Alias

  • ASAT
  • Atm1p
  • EST140535

ABCB7 cDNA / Gene Expression

Ubiquitous expression in duodenum (RPKM 8.8), heart (RPKM 7.5) and 25 other tissues