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Vitronectin/VTN  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
  • Slide 1
10424-H08H-100
10424-H08H-50
100 µg 
50 µg 
Add to Cart
表達宿主: Human Cells  
  • Slide 1
50585-M08H-50
50585-M08H-100
50585-M08H-500
50585-M08H-1
50 µg 
100 µg 
500 µg 
1 mg 
Add to Cart

Vitronectin/VTN 相關信號通路

    Vitronectin/VTN 概述&蛋白信息

    Vitronectin/VTN 研究背景

    基因概述: The protein encoded by VTN gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亞單位結構: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP.
    結構域: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
    亞細胞定位: Secreted, extracellular space.
    組織特異性: Plasma.
    翻譯後修飾: Sulfated on 2 tyrosine residues.
    N- and O-glycosylated (By similarity).
    Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
    Phosphorylation sites are present in the extracellular medium.
    相似的序列: Contains 4 hemopexin repeats.
    Contains 1 SMB (somatomedin-B) domain.
    General information above from UniProt

    Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis. As a multifunctional protein with a multiple binding domain, Vitronectin interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor. It may be an independent predictor of adverse cardiovascular outcomes following acute stenting. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.

    Vitronectin/VTN 別稱

    Vitronectin/VTN 相關文獻

  • Ekmeki OB, et al. (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta. 368(1-2): 77-83.
  • Derer W, et al. (2009) Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2(1): 14-9.
  • Heyman L, et al. (2010) Mesothelial vitronectin stimulates migration of ovarian cancer cells. Cell Biol Int. 34(5): 493-502.
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