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Vimentin  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
10028-H08B-50
10028-H08B-100
50 µg 
100 µg 
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Vimentin 相关研究领域

Vimentin 相關信號通路

    Vimentin 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Vimentin 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    Vimentin 概述&蛋白信息

    Vimentin 研究背景

    基因概述: This VIM gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. Vimentin encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. Vimentin is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. Vimentin functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Vimentin mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
    General information above from NCBI
    亞單位結構: Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B. Interacts with TOR1A; the interaction associates TOR1A with the cytoskeleton. Interacts with TOR1AIP1. Interacts with BCAS3. {ECO:0000269|PubMed:15846844, ECO:0000269|PubMed:16361107, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:18811945, ECO:0000269|PubMed:18827015, ECO:0000269|PubMed:19270731, ECO:0000269|PubMed:20176112, ECO:0000269|PubMed:21746880}.
    結構域: The central alpha-helical coiled-coil rod region mediates elementary homodimerization.
    亞細胞定位: Cytoplasm {ECO:0000269|PubMed:21465480}.
    組織特異性: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. {ECO:0000269|PubMed:2472876, ECO:0000269|PubMed:3371665}.
    翻譯後修飾: Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33. {ECO:0000250, ECO:0000269|PubMed:21465480, ECO:0000269|Ref.14}.; O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. {ECO:0000269|PubMed:20068230}.
    相關疾病 : DISEASE: Cataract 30 (CTRCT30) [MIM:116300]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the intermediate filament family. {ECO:0000305}.
    General information above from UniProt

    Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

    Vimentin 別稱

    HEL113,CTRCT30, [homo-sapiens]
    RP11-124N14.1, [human]
    RP23-185P20.1, [mouse]

    Vimentin 相關文獻

  • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
  • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
  • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.
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