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VEGFR1 / FLT-1 抗體, 兔多抗, 抗原親和純化

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     VEGFR1/Flt1 抗體產品資訊
    免疫原:Recombinant Human VEGFR1 / FLT-1 protein (Catalog#10136-H08H)
    Clone ID:
    Ig類型:Rabbit IgG
    濃度:
    緩衝液:0.2 μm filtered solution in PBS
    抗體製備方法:Produced in rabbits immunized with purified, recombinant Human VEGFR1 / FLT-1 (rh VEGFR1 / FLT-1; Catalog#10136-H08H; P17948-1; Met 1-Asn 756). VEGFR1 / FLT-1 specific IgG was purified by Human VEGFR1 / FLT-1 affinity chromatography.
    Other VEGFR1/Flt1 Antibody Products
    VEGFR1/FLT-1 研究背景

    Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains seven Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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    貨號: 10136-RP02-100
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    Datasheet & Documentation

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