All VDR reagents are produced in house and quality controlled, including 3 VDR Antibody, 30 VDR Gene, 2 VDR Lysate, 2 VDR Protein, 2 VDR qPCR. All VDR reagents are ready to use.
Recombinant VDR proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.
VDRantibodies are validated with different applications, which are ELISA, IHC-P, ICC/IF, IF.
VDRcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each VDR of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDRs repress expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. VDR is expressed in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. It is the nuclear hormone receptor, also called transcription factor that mediates the action of vitamin D3. Inherited mutations in the VDR gene leads to rickets.