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VCAM1/VCAM-1/CD106  Protein, Antibody, ELISA Kit, cDNA Clone

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10113-H07H-200
10113-H07H-100
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100 µg 
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10113-H08H-200
10113-H08H-100
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100 µg 
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10113-H02H-200
10113-H02H-100
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50163-M08H-200
50163-M08H-100
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表達宿主: Human Cells  
50163-M03H-200
50163-M03H-100
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VCAM1/VCAM-1/CD106 相关研究领域

VCAM1/VCAM-1/CD106 相關信號通路

    VCAM1/VCAM-1/CD106 概述&蛋白信息

    VCAM1/VCAM-1/CD106 研究背景

    基因概述: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
    General information above from NCBI
    亞單位結構: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. {ECO:0000250}.
    結構域: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    亞細胞定位: Membrane; Single-pass type I membrane protein.
    組織特異性: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    誘導: By cytokines (e.g. IL-1, TNF-alpha).
    翻譯後修飾: Sialoglycoprotein.
    相似的序列: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    VCAM1/VCAM-1/CD106 別稱

    CD106,INCAM-100, [homo-sapiens]
    CD106,DKFZp779G2333,INCAM-100,MGC99561,VCAM1,VCAM-1, [human]
    CD106,VCAM1,VCAM-1, [mouse]
    CD106,Vcam-1, [mus-musculus]

    VCAM1/VCAM-1/CD106 相關文獻

  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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