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UCHL3 抗體, 兔單抗

    產品資料評論相關產品實驗方法
    大鼠 UCHL3 抗體產品資訊
    免疫原:Recombinant Rat UCHL3 protein (Catalog#80087-R07E)
    Clone ID:028
    Ig類型:Rabbit IgG
    濃度:
    內毒素:
    緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
    抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Rat UCHL3 (rR UCHL3; Catalog#80087-R07E; Q91Y78; Glu2-Ala230).
    Other UCHL3 Antibody Products
    UCHL3 研究背景

    Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase which belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.

    大鼠 UCHL3 參考資料
  • Wood,M.A. et al., 2005, Hippocampus  15 (5):610-21.
  • Kwon,J. et al., 2006, Exp Anim  55 (1):35-43.
  • Setsuie,R. et al., 2009, Neurochem Int  54 (5-6):314-21.
  • Setsuie,R. et al., 2010, Neurochem Int  56 (8):911-8.
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    貨號: 80087-R028-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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