快速訂購

Tie1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
  • Slide 1
10509-H08H-200
10509-H08H-100
200 µg 
100 µg 
Add to Cart

Tie1 相关研究领域

Tie1 相關信號通路

    Tie1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Tie1 概述&蛋白信息

    Tie1 研究背景

    基因概述: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
    General information above from NCBI
    催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
    亞單位結構: Heterodimer with TEK/TIE2.
    亞細胞定位: Cell membrane {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}; Single-pass type I membrane protein {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}.
    組織特異性: Specifically expressed in developing vascular endothelial cells.
    翻譯後修飾: Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. {ECO:0000269|PubMed:15851516}.
    相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 3 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 3 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little to no activity. Embryos deficient in Tie1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. Tie1 is significantly higher in human aortic endothelial cells than in human umbilical vein endothelial cells. Additionally, attachment of cells of monocytic lineage to endothelial cells is also enhanced by Tie1 expression. Collectively Tie1 has a proinflammatory property and may play a role in the endothelial inflammatory diseases such as atherosclerosis.

    Tie1 別稱

    TIE,JTK14, [homo-sapiens]
    JTK14,RP11-282K6.6,TIE,TIE1, [human]
    TIE,D430008P04Rik,RP23-145E1.8,Tie1,tie-1, [mouse]
    TIE,tie-1,D430008P04Rik, [mus-musculus]

    Tie1 相關文獻

  • Chan B, et al. (2008) Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem Biophys Res Commun. 371(3): 475-9.
  • Sato TN, et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 376(6535): 70-4.
  • Rees KA, et al. (2007) The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol. 31(4): 893-7.
  • Kontos CD, et al. (2002) The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 22(6): 1704-13.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”