DR4 (Protein | Antibody | cDNA Clone | ELISA Kit)

All DR4 reagents are produced in house and quality controlled, including 9 DR4 Antibody, 1 DR4 ELISA, 15 DR4 Gene, 3 DR4 Lysate, 3 DR4 Protein, 1 DR4 qPCR. All DR4 reagents are ready to use.

DR4 Protein (3)

DR4 Antibody (9)

DR4 ELISA Kit & Match Antibody ELISA Pair Set ( 1 )

DR4 cDNA Clone (15)


In expression vector

In lentiviral vector

DR4 qPCR Primer (1)

DR4 Lysate (3)

DR4 Background

Tumor necrosis factor receptor superfamily, member 1a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF1A serves as a receptor for the cytotoxic ligand TNFSF1/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy

DR4 References

  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.