快速訂購

TNF-beta/TNFSF1/Lymphotoxin alpha   Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: E. coli  
10270-HNAE-500
10270-HNAE-5
10270-HNAE-20
10270-HNAE-100
10270-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1

TNF-beta/TNFSF1/Lymphotoxin alpha  相关研究领域

TNF-beta/TNFSF1/Lymphotoxin alpha  相關信號通路

TNF-beta/TNFSF1/Lymphotoxin alpha  相關蛋白、抗體、cDNA基因、ELISA試劑盒

TNF-beta/TNFSF1/Lymphotoxin alpha  概述&蛋白信息

TNF-beta/TNFSF1/Lymphotoxin alpha  研究背景

基因概述: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. TNF-beta is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. TNF-beta also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
General information above from NCBI
亞單位結構: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
亞細胞定位: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
相關疾病 : DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
相似的序列: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.

TNF-beta/TNFSF1/Lymphotoxin alpha  別稱

TNF-beta/TNFSF1/Lymphotoxin alpha  相關文獻

  • Messer G, et al. (1991) Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med. 173(1): 209-19.
  • Banner DW, et al. (1993) Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 73(3): 431-45.
  • Picarella DE, et al. (1993) Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol. 150(9): 4136-50.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”