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TNF-alpha/TNFA/TNFSF2  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
10602-H01H-50
10602-H01H-100
10602-H01H-10
50 µg 
100 µg 
10 µg 
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表達宿主: E. coli  
10602-HNAE-500
10602-HNAE-50
10602-HNAE-100
10602-HNAE-10
10602-HNAE-1
500 µg 
50 µg 
100 µg 
10 µg 
1 mg 
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表達宿主: E. coli  
50349-MNAE-500
50349-MNAE-5
50349-MNAE-20
50349-MNAE-100
50349-MNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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表達宿主: E. coli  
80045-RNAE-500
80045-RNAE-5
80045-RNAE-20
80045-RNAE-100
80045-RNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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表達宿主: E. coli  
90330-CNAE-50
90330-CNAE-100
90330-CNAE-10
50 µg 
100 µg 
10 µg 
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表達宿主: E. coli  
90018-CNAE-500
90018-CNAE-5
90018-CNAE-20
90018-CNAE-100
90018-CNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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表達宿主: E. coli  
70003-DNAE-50
70003-DNAE-5
70003-DNAE-100
70003-DNAE-10
50 µg 
5 µg 
100 µg 
10 µg 
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表達宿主: E. coli  
60002-FNAE-5
60002-FNAE-20
60002-FNAE-10
5 µg 
20 µg 
10 µg 
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TNF-alpha/TNFA/TNFSF2 相关研究领域

TNF-alpha/TNFA/TNFSF2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

TNF-alpha/TNFA/TNFSF2 概述&蛋白信息

TNF-alpha/TNFA/TNFSF2 研究背景

基因概述: Tumor necrosis factor (TNF) is a multifunctional proinflammatory cytokine secreted predominantly by monocytes/macrophages that has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF was originally identified in mouse serum after injection with Mycobacterium bovis strain bacillus Calmette-Guerin (BCG) and endotoxin. Serum from such animals was cytotoxic or cytostatic to a number of mouse and human transformed cell lines and produced hemorrhagic necrosis and in some instances complete regression of certain transplanted tumors in mice
General information above from NCBI
亞單位結構: Homotrimer. Interacts with SPPL2B. {ECO:0000269|PubMed:16829951}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted.
翻譯後修飾: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:9034191}.; The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. {ECO:0000269|PubMed:10205166, ECO:0000269|PubMed:8597870}.; O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000269|PubMed:8631363}.
相關疾病 : DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
相似的序列: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

TNF-alpha Protein & Antibody

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

TNF-alpha/TNFA/TNFSF2 別稱

TNF-alpha/TNFA/TNFSF2 相關文獻

  • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
  • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
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